THE STUDY OF THE ANTI-INFLAMMATORY
ACTIVITY OF SOME THIAZOLYL-Δ21,3,4
OXADIAZOLINES AND 5-CARBOXIETHYL-2-
HYDRAZON-4-METHYL-THIAZOLEDERIVATIVES
SMARANDA ONIGA1, ALINA ELENA PÂRVU2, BRÎNDUŞA
TIPERCIUC3, MARIANA PALAGE1, OVIDIU ONIGA3
1Department of Therapeutical Chemistry, Faculty of Pharmacy, „Iuliu
Haţieganu” University, 400023, Cluj-Napoca
2Department of Pathophysiology, Faculty of Medecine, „Iuliu
Haţieganu” University, 400023, Cluj-Napoca
3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, „Iuliu
Haţieganu” University, 400023, Cluj-Napoca
*corresponding author: smaranda72@yahoo.com
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Abstract:

We evaluated the anti-inflammatory potential of some new thiazolyl-1,3,4-
oxadiazolines and 5-carboxiethyl-2-hydrazon-4-methyl-thiazoles using an acute model of inflammation, by intramuscular administration of turpentine oil in which the response of the hematogen marrow (number of leukocytes, leukocitary formula and the degree of activation of the circulatory phagocytes) and the nitrate/nitrite levels, metabolites of NO have been determined. The experimental study was performed on rats. Four of the tested compounds showed a good anti-inflammatory potential, compared with diclofenac.

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