IN VITRO DRUG RELEASE FROM TOPICAL
ANTIFUNGAL PHARMACEUTICAL FORMULATIONS
OANA MĂNESCU1*, DUMITRU LUPULEASA1, DALIA SIMONA
MIRON2, EMMA ADRIANA BUDURA1, FLAVIAN ȘTEFAN
RĂDULESCU3
University of Medicine and Pharmacy „Carol Davila” Bucharest,
Faculty of Pharmacy, 6 Traian Vuia St., 020956, Bucharest, Romania
1Pharmaceutical Technology Department
2Physics and Informatics
3Drug Industry and Pharmaceutical Biotechnologies
*corresponding author: oana_manescu2003@yahoo.ca
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Abstract:

The paper presents the evaluation of the diffusion profiles obtained for ciclopirox olamine, naftifine hydrochloride and terbinafine hydrochloride from liquid and semisolid topical dosage forms, using a vertical diffusion cells system (VDC). The aim was to evaluate the in vitro kinetics of the drugs’ release, including both formulation characteristics and the drugs’ physico-chemical properties in the analysis of the results. The in vitro drug release parameters are highly dependent on the formulation factors, a considerable influence being assigned to the drug solubility within the pharmaceutical vehicle, but also to the viscosity and its role in the overall diffusion resistance. The apparent ranking of the diffusion coefficient values for each drug product confirmed the theoretical biopharmaceutical assumptions, but the biological relevance is dependent upon the experimental conditions (mainly the nature of membrane interface and/or receptor media).

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