SYNTHESIS OF SOME 2-(ACETOPHENONHYDRAZIN)-
THIAZOLES AND 2-(4-THIAZOLYLMETHYNHYDRAZIN)-
THIAZOLES AS POTENTIAL ANTIBACTERIAL AND
ANTIFUNGAL AGENTS.
OVIDIU ONIGA1*, CRISTINA MOLDOVAN1, SMARANDA ONIGA1,
BRÎNDUŞA TIPERCIUC1, ADRIAN PÂRNĂU2, PHILIPPE VERITE3,
OVIDIU CRIŞAN1, IOANA IONUŢ1
1“Iuliu Haţieganu” University of Medicine and Pharmacy, Faculty of
Pharmacy, 12 Ion Creangă Street, RO-400010 Cluj Napoca, Romania
2National Institute for Research and Development of Isotopic and
Molecular Technologies, RO-400293 Cluj Napoca, Romania
3University of Medicine and Pharmacy Rouen, Faculty of Pharmacy,
Department of Analytical Chemistry, 22 Boulevard Gambetta, F-76183
Rouen Cedex, France
*corresponding author: onigao65@yahoo.com
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Abstract:
A new series of 2-(acetophenon-hydrazin)-thiazoles 4a-x and 2-(4-thiazolylmethine- hydrazin)-thiazoles 5a-c were synthesized starting from various thiosemicarbazones by the reaction with different α(γ))-halocarbonyle compounds. The newly synthesized compounds were characterized by IR, 1H-NMR and mass spectral studies.
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