ATORVASTATIN INFLUENCE ON GLYCEMIC
CONTROL IN PATIENTS WITH TYPE 2
DIABETES MELLITUS.
FLORIANA ELVIRA IONICĂ1*, CĂTĂLINA PISOSCHI2, SIMONA
NEGREŞ4, RIGAS F. NIKOS5, MIHAI TĂRÂŢĂ3, FLORICA POPESCU1
University of Medicine and Pharmacy Craiova
1 Farmacology Department
2 Biochemistry Department
3Medical Informatics
4University of Medicine and Pharmacy "Carol Davila" Bucharest
5PhD student, University of Medicine and Pharmacy Craiova
* corresponding author: floriana_umf@yahoo.com
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Abstract:

In type 2 diabetes mellitus (DM 2) clinical consequences of atherosclerosis
represent the main cause of mortality. LDL cholesterol and atherosclerosis are related in both healthy and diabetic subjects but the predisposition for atheroma is higher for those with DM 2, although their LDL cholesterol levels are similar to those of healthy subjects.
This is because LDL particles are altered under diabetic conditions and become more atherogenic.
In our study we evaluated the efficacy of atorvastatin and found that the treatment with oral antidiabetic agents in combination with atorvastatin contributes to an improvement of glycemic control, the combined therapy being more effective than oral antidiabetics alone.

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