DETERMINATION OF SCOPOLETIN IN
PHYSALIS ALKEKENGY AND SOLANUM
DULCAMARA BY HIGH-PERFORMANCE LIQUID
CHROMATOGRAPHY.
CLAUDIA BUTNARU 1*, ELENA BUTNARU 1, LAURIAN VLASE 2,
MIHAI IOAN LAZĂR 1
1University of Medicine and Pharmacy „Gr. T. Popa”, Faculty of
Pharmacy, 16 University Street, 700115, Iaşi, Romania
2University of Medicine and Pharmacy „Iuliu Haţieganu”, Faculty of
Pharmacy, 13 Emil Isac, 400023, Cluj-Napoca, Romania
*corresponding author: butclaudia@yahoo.com
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Abstract:

The paper presents the results of the qualitative and quantitative determination of scopoletin (SLT) in Physalis alkekengi and Solanum dulcamara (Solanaceae) by highperformance liquid chromatography tandem mass spectrometry (HPLC/MS). The plant samples were harvested around Iasi on July 2007, July 2008, August-September 2009.
Scopoletin was extracted from dried leaves by two methods: with methanol 70% by reflux and with ethanol 70%. Hydrolyzed samples showed significant levels of scopoletin: for Physalis alkekengy the values were between 83.32 and 267.90 mg/ 100 g product and for Solanum dulcamara: 123.13 and 438.93 mg/ 100 g product. The mean values are lower for Physalis alkekengi compared with those for Solanum dulcamara.

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