PREPARATION AND CHARACTERISATION OF
INCLUSION COMPLEXES OF MELOXICAM AND
α-CYCLODEXTRIN AND β-CYCLODEXTRIN.
LENUŢA - MARIA MICLEA1*, LAVINIA VLAIA1, V. VLAIA2,
DANIEL I. HĂDĂRUGĂ3, CONSTANTIN MIRCIOIU4,
1University of Medicine and Pharmacy “Victor Babes”, Faculty of
Pharmacy, Department of Pharmaceutical Technology, P-ta Eftimie
Murgu 2, 300041, Timişoara, Romania
2University of Medicine and Pharmacy “Victor Babes”, Faculty of
Pharmacy, Department of Organic Chemistry, P-ta Eftimie Murgu 2,
300041, Timişoara, Romania
3Politehnica University of Timişoara, Faculty of Industrial Chemistry
and Environmental Engineering, Applied Chemistry and Organic-
Natural Compounds Engineering, 300006-Timişoara, P-ţa Victoriei 2,
Romania
4University of Medicine and Pharmacy “Carol Davila”, Faculty of
Pharmacy, Department of Applied Mathematics and Biostatistics, Traian
Vuia 6, 020956, Bucharest, Romania
*corresponding author: marymicumftm@yahoo.com
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Abstract:

Meloxicam (ME) belongs to the thiazines antiinflammatory (AI) class, has antiinflammatory action, and is characterized by a low solubility in water. In order to increase its solubility in water, inclusion complexes of meloxicam with α-cyclodextrin (α- CD) and β-cyclodextrin (β-CD) were obtained.
In order to obtain the complexes as particles of small (nanometric) dimensions, complexation by the co-precipitation, kneading and ethanol-water solution methods was used.
The obtained inclusion complexes were characterized through Scanning Electron Microscopy (SEM) for the evaluation of the crystals’ morphology and their approximate size and through thermal analysis using the thermogravimetric (TG) method and differential scanning calorimetry (DSC).
The results obtained confirm the inclusion of meloxicam in the cyclodextrin
cavity.

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