SYNTHESIS, CHARACTERIZATION AND
BIOLOGICAL ACTIVITY OF SOME
α-AMINOPHOSPHONATES.
NICOLAE ONIŢA1*, IOANA ŞIŞU1, MIRCEA PENESCU3,4*, VICTOR
LORIN PURCAREA4, LUDOVIC KURUNCZI1,2*
1Romanian Academy, Institute of Chemistry Timişoara, 300223 Mihai
Viteazul bd., no. 24, Timişoara, Romania
2University of Medicine and Pharmacy “Victor Babeş” Timişoara,
Faculty of Pharmacy, 300041 Eftimie Murgu Sq., no. 2, Timişoara,
Romania
3“Carol Davila” Hospital of Nephrology, no. 4, Calea Grivitei str.,
010701 Bucharest, Romania
4University of Medicine and Pharmacy “Carol Davila”, no. 37, Dionisie
Lupu str., 020021 Bucharest, Romania
*corresponding authors: onita61@yahoo.com, kurunczi@umft.ro
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Abstract:

A series of 12 aminophosphonates (AMPP) were synthesized, characterized
and tested for their potential biological activity. The antioxidant activity was tested in experimental assays with DPPH• (1,1-diphenyl-2-picryl-hydrazyl) and the potential to function as herbicides, in red blood cells (RBC) membrane destruction experiments. Regarding the reaction with DPPH• at least 3 aminophosphonates are better antioxidants than 2,6-di-tert-butyl-4-methylphenol (BHT). Aminophosphonates’ capacity to function as herbicide (demonstrated through their hemolytic activity) is given by the presence in their structure of some shorter aliphatic substituents and / or more benzenic nuclei.

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