RELATIONSHIPS BETWEEN ERYTHROCYTE
Na+/K+-ATPase ACTIVITY, OXIDATIVE STRESS
AND HIGH BLOOD PRESSURE IN
HYPERTENSIVE DIABETIC PATIENTS.
ALEXANDRA TOTAN^1*, MARIA GREABU¹, NICULINA MITREA²,
MARIA MOHORA³, ANDREEA LETIȚIA ARSENE²
1University of Medicine and Pharmacy “Carol Davila”, Faculty of Dental
Medicine, Department of Biochemistry
2University of Medicine and Pharmacy “Carol Davila”, Faculty of
Pharmacy, Department of Biochemistry
3University of Medicine and Pharmacy “Carol Davila”, Faculty of
Medicine, Department of Biochemistry
*corresponding author: alexandratotan@yahoo.com
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Abstract:

Diabetes mellitus is a chronic disease frequently associated, at molecular level, with an imbalance between reactive oxygen species (ROS) generation and antioxidant defence systems in the body. ROS production can damage arterial walls including an impairment of the endothelium-dependent vasodilatation or endothelial dysfunction. Na⁺/K⁺-ATPase is an antioxidant plasma membrane-associated protein complex whose activity has been found to be altered in various cell types under diabetic conditions. The aim of the present study was to test if there are relationships between the activity of erythrocyte Na⁺/K⁺-ATPase and high blood pressure in the context of diabetes mellitus..

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