THE INFLUENCE OF DIFFERENT POLYMERS
ON THE PHARMACO-TECHNOLOGICAL
CHARACTERISTICS OF PROPICONAZOLE
NITRATE BIOADHESIVE OROMUCOSAL
TABLETS.
ANDREEA STANESCU¹, LACRAMIOARA OCHIUZ², ILEANA
COJOCARU², IULIANA POPOVICI^2*, DUMITRU LUPULEASA¹
1 The University of Medicine and Pharmacy ”Carol Davila” Bucharest,
The Faculty of Pharmacy, 6, Traian Vuia Street, 020956, Bucharest,
Romania
2 The University of Medicine and Pharmacy ”Gr. T. Popa”, Iasi, The
Faculty of Pharmacy, 16, University Street, 700115, Iasi, Romania
∗corresponding author: popoviciiuliana19@yahoo.com
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Abstract:

The objective of this study is the formulation, the preparation and determination of the physical quality parameters of the 1.5% propiconazole nitrate biomucoadhesive oral tablets, based on the reticulated polymers of the acrylic acid and hydroxypropyl cellulose, with or without chitosane, as hydrophilic polymers with optimal bioadhesive properties. There have been studied and prepared 8 formulas: F1-F4 contain 20% hydrophilic polymers: Carbopol 71, Carbopol 974, Carbopol 934, or hydroxypropyl cellulose (HPC-H); F5-F8 are similar formulas to the first four, but with 6% chitosane.
The formulations with Carbopol 974, 934 and those that contain chitosane needed the addition of lubricants to improve the flow properties of the powder mixture. The results of the pharmaco-technical characterizations of the tablets have confirmed the flowing properties and the compressibility of the studied formulations. After a direct compressing process we obtained tablets with variations within the limits of 10th Romanian Pharmacopoeia and U.S.P. 32 (United States Pharmacopeia) for mass uniformity, diameter, thickness, hardness, friability and disintegration time. The swelling degree and the contact surface decreased, depending on the type of the polymer used, as follows: C974 > C934 > HPC- H > C71. The formulations with chitosane associated proved a superior swelling degree during the first 2-3 hours and also the best biomucoadhesion times, due to the bioadhesive properties of the chitosane. The pH acid values at the surface of the tablets recommend the use in the formulation of a buffer in order to assure a pH value close to the physiologic values, thus preventing the irritative effect at the aplication site.

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