INDIVIDUALIZED DRUG RESPONSE RELATED
TO GENETIC VARIATIONS OF CYTOCHROME
P450 ISOFORMS AND OTHER ENZYMES.
MARIAN SORIN PAVELIU1, SIMONA BENGEA1*, FRAGA SILVIA
PAVELIU2
1”Titu Maiorescu” University, Faculty of Medicine and Dental Medicine,
Department of Pharmacology, Bucharest, Romania
2”Dr. Paveliu” Medical Civil Society, Bucharest, Romania
*corresponding author: simona.luculescu@gmail.com
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Abstract:
Gene polymorphism and single nucleotide polymorphism (SNPs) called "snips"might play a pivotal role in the future of the clinical therapy. Although not much is known about the distribution of SNPs in population and about the gene polymorphism of the drugmetabolizing enzymes, their investigation could represent an important tool in order to determine the precise therapy for maximum efficacy. SNPs represent a DNA sequence variation of a single nucleotide, variation that could determine and alter the genome sequence. If just one nucleotide (A - adenine, C - citosine, G - guanine, T - thymine) is changed this will definitely bring a change in the DNA sequence. In order to improve public health, since the map of the genome was created, scientists thought about new SNPs maps, which will bring a new vision in diagnosis, biological markers, drug therapy, and human response to disease. This review brings some insights in the knowledge of gene polymorphism regarding their impact on drug therapy and disease.
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