SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME NEW PYRAZOLE DERIVATIVES.
GEORGE MIHAI NIŢULESCU1*, HORIA PĂUNESCU2,
CONSTANTIN DRĂGHICI3, ALEXANDRU-VASILE MISSIR1,
OANA ANDREIA COMAN2, ION FULGA2
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Carol
Davila” University of Medicine and Pharmacy, Traian Vuia, 6, 020956,
Bucharest, Romania
2Department of Pharmacology and Pharmacotherapy, Faculty of
Medicine, “Carol Davila” University of Medicine and Pharmacy, Eroilor
Sanitari, 8, 050474, Bucharest, Romania
3The Organic Chemistry Center of Romanian Academy "Costin D.
Nenitescu”, Splaiul Independentei, 202B, 77208, Bucharest, Romania
*corresponding author: nitulescu_mihai@yahoo.com
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Abstract:
In search of bioactive molecules in the class of functionally substituted heterocyclic compounds, we synthesized some new N-(1-methyl-1H-pyrazole-4-carbonyl)-thiourea derivatives and evaluated their analgesic and sedative effects. The obtained compounds were characterized by elemental analysis, IR and NMR spectroscopic analyses and evaluated for their analgesic and sedative effects.
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