SYNTHESIS OF 2-(3,4-DIHYDRO-3-OXO-2H- [1,2,4]TRIAZINO[4,3-c]QUINAZOLIN-4-YL)ACETIC ACID DERIVATIVES AS POTENTIAL
ANTIOXIDANTS IN NITROSATIVE STRESS MODEL.
SERGEY I. KOVALENKO1, IGOR F. BELENICHEV2, VADIM V.
GALITSA2, OKSANA V. KRIVOSHEY1
1Department of Pharmaceutical Chemistry, Zaporozhye State Medical
University, Maykovsky ave. 26, 69035 Zaporozhye, Ukraine
2Department of Pharmacology, Zaporozhye State Medical University,
Maykovsky ave. 26, 69035 Zaporozhye, Ukraine
* corresponding autor: kovalenkosergiy@gmail.com
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Abstract:
The esters (3a-f) and amides (4a-c) of 2-(3,4-dihydro-3-oxo-2H- [1,2,4]triazino[4,3-c]-quinazolin-4-yl)acetic acid were synthesized by prior esterification or aminolysis of the acid 2. The structure of the synthesized compounds was confirmed by spectroscopic investigations. Almost all substances, which have been tested in vitro for the antioxidant activity in nitrosative stress, have shown significant antioxidant activity in comparison with N-acetylcystein (N-ACC). Compound 3f revealed the best antioxidant properties in a nitrosative stress model.
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