PREPARATION AND CHARACTERIZATION OF INCLUSION COMPLEXES BETWEEN REPAGLINIDE AND β – CYCLODEXTRIN, 2 – HYDROXYPROPYL - β – CYCLODEXTRIN AND RANDOMLY METHYLATED β – CYCLODEXTRIN.
CAMELIA NICOLESCU*, CORINA ARAMĂ, CRINA-MARIA MONCIU
University of Medicine and Pharmacy „Carol Davila”, Faculty of
Pharmacy, Analytical Chemistry Department, 6 Traian Vuia, 020956,
Bucharest, Romania
*corresponding author: nicolescu_camelia@yahoo.com
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Abstract:
Repaglinide, an oral antidiabetic drug with short duration of action, administered in patients with type 2 diabetes mellitus exhibits very low water solubility and high lipophilicity. In order to evaluate the possibility of enhancing the drug’s solubility, inclusion complexes between repaglinide and β- cyclodextrin(β CD), 2- hydroxypropyl-β cyclodextrin (HP- β-CD) and randomly methylated-β cyclodextrin (RAMEB)) have been obtained by applying the following preparation methods: liophylisation, co-precipitation followed by filtration of the end-product and kneading method.
The inclusion complexes were characterized by means of Nuclear Magnetic
Resonance (1H-NMR, 13C-NMR), Differential Scanning Calorimetry (DSC) and Infrared Spectroscopy (FT-IR). The results obtained confirmed the inclusion of repaglinide into the cyclodextrins cavity.
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