IN VITRO EVALUATION OF THE ANTIBACTERIAL AND ANTIFUNGAL
ACTIVITY OF SOME NEW N-(2-DIALKYLAMINOETHYL)BENZANILIDES.
DIANA CAMELIA NUŢĂ^1*, CARMEN BALOTESCU CHIFIRIUC²,
ALEXANDRU VASILE MISSIR¹, ILEANA CORNELIA CHIRIŢĂ¹,
CARMELLINA DANIELA BĂDICEANU¹
1 University of Medicine and Pharmacy „Carol Davila”Bucharest,
Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 6
Traian Vuia, 020956, Bucharest, Romania
2Microbiology-Immunology Department, Faculty of Biology, University
of Bucharest, Ale. Portocalelor 1-3, sect. 5, Bucharest, Romania
*corresponding author: diananuta@yahoo.com
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Abstract:

The use of most antimicrobial agents is presently limited worldwide, not only by the rapidly developing drug resistance, but also by the unsatisfactory status of present treatment of bacterial and fungal infections and drug side effects. Therefore the development of new and different antimicrobial drugs is an important objective and many research studies are directed towards the design of new agents. Recently substituted anilides have received considerable attention because some of them are generally considered good bacterostatic and fungistatic substances. The present study is a follow-up paper to the previous articles dealing with the biologically active amides as potential antimicrobial drugs. In our laboratory we obtained new N-(2-dialkylaminoethyl)benzanilides which were tested to determinate the minimal inhibitory concentration (MIC) in order to evaluate their in vitro antimicrobial and antifungal activity. The importance of substituents in the benzoyl ring and in the anilide moiety for optimal activity have been noted..

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