NEW THIOUREIDES OF 2-THIOPHENEACETIC
ACID WITH POTENTIAL PHARMACOLOGICAL
ACTIVITY. NOTE 2..
CARMELLINA DANIELA BĂDICEANU¹, ALEXANDRU MISSIR¹,
CONSTANTIN DRĂGHICI², CRISTINA LARION³
1Pharmaceutical Chemistry Department, Faculty of Farmacy, „Carol
Davila” University of Medicine and Pharmacy , Traian Vuia 6, sect. 2,
020956, Bucharest, Romania
2The Organic Chemistry Center of Romanian Academy "Costin C.D.
Nenitescu” Bucharest, Splaiul Independentei, 202B, 77208, Romania
3Microbiology-Immunology Department, Faculty of Biology, University
of Bucharest, Ale. Portocalelor 1-3, sect. 5, Bucharest, Romania
* corresponding author: bcarmellina@yahoo.com
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Abstract:

In this paper we present the synthesis of new thioureides from 2-thiopheneacetic acid performed by the addition of various primary aromatic amines to the 2-thienyl isothiocyanate. The best reaction conditions in order to obtain with good yields high pure compounds were established. The chemical structure and the purity of the new compounds were confirmed by ¹H-NMR and ¹³C-NMR spectra. The obtained substances were tested by qualitative and quantitative methods on various microbial and fungal strains.

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