HORMONAL PROFILE IN SUBJECTS WITH
METABOLIC SYNDROME.
RUCSANDRA DĂNCIULESCU MIULESCU1, MĂDĂLINA MUŞAT1,
CĂTĂLINA POIANĂ1, SUZANA DĂNOIU2
1“Carol Davila” University of Medicine and Pharmacy, Bucharest
2University of Medicine and Pharmacy Craiova
*corresponding author: rucsandra_m@yahoo.com
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Abstract:
The term “Metabolic Syndrome” is generally used to indicate a clinical situation in which different degrees of hypertension, impaired glucose tolerance, atherogenic dyslipidemia, central fat accumulation, insulin resistance, as well as prothrombotic and proinflammatory states cluster together in the same individual. The etiology of the metabolic syndrome has not been established definitively. One hypothesis presumes that the primary cause is insulin resistance. Another hypothesis incriminates hormonal changes for the development of abdominal obesity. The aim of the present study is to evaluate the interaction of hormones with features of metabolic syndrome.
18 patients with metabolic syndrome were recruited for this study. Subjects were fasting for 12 h before blood sampling, which was done between 8.00 and 9.00 a.m. Serum growth hormone (GH), insulin like growth factor 1 (IGF-1), cortisol, insulin, glucose, triglycerides, and HDL were measured. Estimates of insulin resistance were derived from the HOMA (Homeostasis Model Assessment) index (basal glucose mmol/l x basal insulin μIU/ml/22.5); insulino-resistant were defined by HOMA >3. Results were compared with measurements in 12 healthy subjects.
There were statistically significant differences in the recorded parameters in
patients with metabolic syndrome versus control group.
Fasting blood glucose, basal insulin, HOMA, serum triglycerides were higher in patients with the metabolic syndrome supporting the concept that these patients have a higher cardiovascular risk. Most subjects had hormone levels within the normal range, but there were significant difference between mean levels of metabolic syndrome group when they were compared to control group. Cortisol levels in patients with metabolic syndrome are within the normal range, but significantly higher compared to control group. The results sustain the hypothesis that cortisol is critical for the development and maintenance of abdominal visceral obesity. The levels of the growth hormone and insulin like growth factor-I are within the normal range, but the metabolic syndrome group had an increased IGF-1 associated with the decrease of GH concentrations.
Hormonal profile of patients with metabolic syndrome in this study suggests an excess of morning plasma cortisol and lower GH levels in association with central adiposity, as compared to control group. However a bigger cohort is necessary to confirm these preliminary data.
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