MODEL FOR ENZYME KINETICS USING
PETRI NETWORKS.
RADU DOBRESCU1, ŞTEFAN A. POPA1, VICTOR PURCAREA2,
CĂTĂLIN VASILESCU2
1“Politehnica” University of Bucharest, Automatic Control and Computers
Science Faculty, 313 Splaiul Independentei Bucharest, Romania
2University of Medicine and Pharmacy “Carol Davila”, 37 Dionisie
Lupu st., Bucharest, Romania
*corresponding author: e-mail: radud @isis.pub.ro
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Abstract:
In this paper we propose a model for single substrate enzyme kinetics based on the differential Petri network formalism. Metabolic signaling pathways imply biochemical reactions in which substrates are enzyme catalyzed and turn them into active biochemical products. The enzymatic reactions are described quantitatively through ordinary differential equations (ODEs) in the proposed Petri network model. The specificity of the biochemical reactions are captured in the proposed Petri network model. The simulation study shows qualitative validation of the dependability of the proposed Petri network model with experimental results for enzyme kinetics..
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