SYNTHESIS AND CHARACTERIZATION OF
SOME NOVEL AZODERIVATIVES.
GABRIELA RĂU1*, GEORGE-DAN MOGOŞANU2, CAMELIA
ELENA STĂNCIULESCU3
1Department of Organic Chemistry & Medicinal Chemistry
2Department of Pharmacognosy & Phytotherapy
3Department of Biochemistry
University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy,
2–4 Petru Rareş Street, 200349 Craiova, Romania
*corresponding author: gabirau@iname.com, gabirau@umfcv.ro
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Abstract:
The paper presents 15 novel azoderivatives, obtained by the condensation of
2-methyl-N-chloroacetylaniline or 2-ethoxy-N-chloroacetylaniline with 4-(phenylazo) phenols
4’-substituted or not, or with 4-hydroxy-4’-(phenylazo) biphenyls 4”-substituted or not, These
new compounds have been characterized using physical methods (UV–Vis, IR, 1H–NMR and
Mass Spectra). The molecular modelling of the chemical structures, concerning molecular
descriptors for QSPR (Quantitative Structure Property Relationship), was performed with
Hyperchem 6.0, MM+ (Molecular Mechanics) method, CODESSA and MOPAC 6.0 soft
packages. The phytobiological activity (Triticum test) was determined for the novel
azoderivatives.
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