TOPICAL W/O/W DOUBLE EMULSIONS OF
PIROXICAM: IN VITRO DRUG RELEASE STUDY.
LAVINIA VLAIA1, VICENŢIU VLAIA2, LENUŢA-MARIA MICLEA1,
IOANA OLARIU1, GEORGETA CONEAC1
University of Medicine and Pharmacy „Victor Babes”, Faculty of
Pharmacy, P-ta Eftimie Murgu, No. 2, 300041, Timişoara, Romania
1Department of Pharmaceutical Technology
2Department of Organic Chemistry
*corresponding author: laviniaursica@yahoo.com
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Abstract:
The aim of this work was to study the in vitro release of piroxicam suspended in
the internal phase of some W/O/W (water/oil/water) double emulsions and to investigate
the effect of hydrophilic macromolecules (hydroxyethylcellulose and Carbopol 940) in the
external aqueous phases of W/O/W double emulsions on the diffusion profiles of piroxicam
through synthetic membranes. W/O/W double emulsions, containing 1% piroxicam and
80% W/O primary emulsion, were prepared using liquid paraffin, Span 80 and Tagat S2, by
a two-step emulsification procedure. The results of the in vitro study showed a slow release
of piroxicam from W/O/W double emulsions; the release was affected by the presence of
hydrophilic macromolecules.
It was concluded that the release of piroxicam from the studied W/O/W double
emulsions occurs either by molecular diffusion through the oily intermediary film as well as
by the rupture of this film and is controlled by the viscosity and the stability of the systems.
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