SYNTHESIS AND PHYSICO-CHEMICAL CHARACTERIZATION OF SOME QUATERNARY AMMONIUM SALTS OF 2-ARYL THIAZOLE DERIVATIVES.
MARIANA PALAGE¹, SMARANDA ONIGA¹, ADRIAN PARNAU²,
VALENTIN ZAHARIA³, CRENGUŢA BELEGAN⁴, LAURIAN
VLASE⁵, ANA MURESAN¹
1Department of Therapeutical Chemistry, University of Medicine and
Pharmacy “Iuliu Haţieganu” Cluj-Napoca, Ion Creanga, 12, 400010
2National Institute for Research and Development of Isotopic and
Molecular Technology, Cluj-Napoca
3Department of Organic Chemistry, University of Medicine and
Pharmacy “Iuliu Haţieganu” Cluj-Napoca
4Department of Epidemiology and Prevention in Medicine, University of
Medicine and Pharmacy, Târgu-Mureş
5Department of Pharmaceutical Tehnology, University of Medicine and
Pharmacy “Iuliu Haţieganu” Cluj-Napoca
*corresponding author: palage14@yahoo.com


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Abstract:

New quaternary ammonium compounds, having at the basis the 2-aryl-thiazole system diversely substituted at the 2, 4, and 5 positions, have been synthesized.
The basic component is represented by tertiary amines in which the nitrogen is included either into an aromatic heterocycle (pyridine, quinoline), or into a tertiary cyclic amine (N-methyl-pyperidine, N-methyl-morpholine).
The benzenic ring in the 2 position can be substituted or not. The selected
substituents are electron-donating (methyl), or electron-attracting (chlorine).
In order to elucidate the structure of the synthesized compounds, UV, IR,
Raman, Mass and ¹H-NMR spectroscopy were performed.
The bactericide activity of the new compounds has been evaluated against two strains of germs: Staphylococcus aureus and Pseudomonas aeruginosa.

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