SYNTHESIS OF ISOMERIC N-(1-METHYL-1HPYRAZOLE-
4-CARBONYL)-N’-(XYLYL)- THIOUREA AND THEIR ANTIMICROBIAL
EVALUATION.
GEORGE MIHAI NIŢULESCU^1*, CONSTANTIN DRĂGHICI²,
MARIANA-CARMEN CHIFIRIUC³, ALEXANDRU-VASILE MISSIR¹
1“Carol Davila” University of Medicine and Pharmacy, Faculty of
Pharmacy, Department of Pharmaceutical Chemistry, Traian Vuia, 6,
020956, Bucharest, Romania
2The Organic Chemistry Center of Romanian Academy "Costin D.
Nenitescu”, Splaiul Independentei, 202B, 77208, Bucharest, Romania
3University of Bucharest, Faculty of Biology, Microbiology Immunology
Department, Ale. Portocalelor 1-3, 060101, Bucharest, Romania
*corresponding author: nitulescu_mihai@yahoo.com
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Abstract:

In search of bioactive molecules in the class of functionally substituted
heterocyclic compounds, we synthesized some new N-(1-methyl-1H-pyrazole-4-carbonyl)-thiourea derivatives and evaluated their in vitro antimicrobial activity on several pathogen bacteria. The newly obtained compounds were characterized by elemental analysis, IR and NMR spectroscopic analyses..

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