DISINTEGRANT PROPERTIES OF A
PARACETAMOL TABLET FORMULATION
LUBRICATED WITH CO - PROCESSED
LUBRICANTS.
ALEBIOWU, GBENGA* AND ADEAGBO, ADEWOLE ADEBOLU
Department of Pharmaceutics, Faculty of Pharmacy,
Obafemi Awolowo University, Ile-Ife, Nigeria
*corresponding author: galebiowu@oauife.edu.ng;
galebiowu@rediffmail.com; galebiowu@yahoo.co.uk
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Abstract:

In this study, cocoa butter co-processed with a combination of magnesium stearate and talc (CMT) was evaluated as a lubricant in a paracetamol tablet formulation. In the evaluation study the disintegrant properties - tablet disintegration time (DT) and crushing strength friability/disintegration time ratio (CSFR/DT) of paracetamol tablets prepared from granules lubricated with CMT were compared with tablets prepared from granules lubricated with combination of magnesium stearate and talc (MT) alone. The study reveals that the lubricant type and concentration influenced the disintegrant properties, and that the co - processed lubricant could be useful in situations where a low CSFR/DT ratio is required e.g. sustained release tablets.

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