SYNTHESIS OF A NEW SERIES OF THIAZOLYLMETHYL(
CARBONYL-METHYL)-OXIBENZALDEHYDE
DERIVATIVES.
CRISTINA MOLDOVAN1*, OVIDIU ONIGA1, BRÎNDUŞA TIPERCIUC1,
PHILLIPPE VERITE2, ADRIAN PÎRNĂU3, MARIUS BOJIŢĂ1
1“Iuliu Haţieganu” University of Medicine and Pharmacy, Faculty of
Pharmacy, 12 Ion Creangă Street, RO-400010 Cluj Napoca, Romania
2University of Medicine and Pharmacy Rouen, Faculty of Pharmacy,
Department of Analytical Chemistry, 22 Boulevard Gambetta, F-76183
Rouen Cedex, France
3National Institute for Research and Development of Isotopic and
Molecular Technologies, RO-400293 Cluj Napoca, Romania
*corresponding author: cris.moldovan@yahoo.com
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Abstract:

A new series of thiazolyl-methyl (carbonyl-methyl)-oxi-benzaldehydes (5, 8-12) was prepared by the reaction between a series of 2-aryl-thiazoles and o, m or p-OH benzaldehyde. The obtained aldehydes were used as key intermediates for the synthesis of 2-thioxo-1,3-thiazolidin-4-one derivatives (13-16) and of pyrimidine-2,4,6-trione derivatives (17-19). The structures of the newly synthesized compounds were confirmed by TLC, elemental analysis and spectroscopic (MS, IR, ¹H NMR) data.

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