EVALUATION OF ANTIINFLAMATORY
ACTIVITY OF LIPOSOME ENCAPSULATED
SUPEROXIDE DISMUTASE IN RATS
PERITONITIS.
ALINA SILVIA PORFIRE1*, ALINA ELENA PÂRVU2,
DOINA DAICOVICIU3, S.E. LEUCUŢA1
1Department of Pharmaceutical Technology and Biopharmaceutics,
Faculty of Pharmacy, “Iuliu Hatieganu” University, 400023, Cluj-
Napoca, Romania
2 Department of Pathophysiology, Faculty of Medicine
3 Department of Physiology, Faculty of Medicine
*corresponding author: aporfire@umfcluj.ro
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Abstract:

This work describes the effect of superoxid dismutase (SOD) in the prevention and treatment of chemical induced peritonitis in rats. SOD was administered i.p., both as a solution and loaded in liposomes, in a dose of 500 U/kg body weight. SOD efficiency was compared with diclofenac, vitamin E and a nonselective nitric oxide synthase inhibitor, Nnitro L-arginine methyl ester, noted as NAME. The antiinflamatory effect was evaluated through bone marrow acute phase response and some global and specific oxidative stress parameters. SOD liposomes were more efficient than the solution of SOD in the prevention of peritonitis and their effect was similar in the treatment of peritonitis.




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