REDOX-SENSITIVE SIGNALING FACTORS
AND ANTIOXIDANTS.
MARIA MOHORA1* MARIA GREABU2, ALEXANDRA TOTAN2,
NICULINA MITREA3, MAURIZIO BATTINO4
1“Carol Davila” University of Medicine and Pharmacy, Faculty of
Medicine, Department of Biochemistry, Bucharest, Romania
2"Carol Davila" University of Medicine and Pharmacy, Faculty of Dental
Medicine, Department of Biochemistry, Bucharest, Romania
3“Carol Davila” University of Medicine and Pharmacy, Faculty of
Pharmacy, Department of Biochemistry, Bucharest, Romania
4Institute of Biochemistry, Faculty of Medicine, Universita Politecnica
delle Marche, Ancona, Italy
*corresponding author: mohoramaria@yahoo.com
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Abstract:

The redox state, like the pH or the osmotic pressure, represents chemical characteristics of the intracellular environment. The intracellular redox homeostasis can be disturbed by the installation of the “oxidative stress”, which manifests itself through the dysregulation of the balance between the systems that produce oxidant agents and the antioxidant defense mechanisms (the redox balance). Essential cellular functions, such as gene expression, are influenced by the balance between pro- and antioxidant conditions. The mechanism by which the transcription of specific eukaryotic genes can be redox regulated, is complex, however, recent findings suggest that redox-sensitive transcription factors play an essential role in this process. This review is focused on the recent knowledge concerning some eukaryotic transcription factors, whose activation and DNA binding is controlled by the thiol redox status of the cell.

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