ANTINOCICEPTIVE, ANTI-INFLAMMATORY
AND ANTIPYRETIC EFFECTS OF A
FLAVONOIDAL MIXTURE LEAF SURFACE OF
RHUS RETINORRHAEA.
SALEH ALQASOUMI¹, AHMED GALAL², ALI GAMAL¹,
MOHAMMED AL-YAHYA¹, SYED RAFATULLAH¹*
1Department of Pharmacognosy and Medicinal, Aromatic & Poisonous
Plants Research Center (MAPPRC), College of Pharmacy, P.O. Box
2457, King Saud University, Riyadh 11451, Saudi Arabia
2NCNPR, College of Pharmacy, University of Mississippi, MS 38677, USA
*corresponding author: srafat@ksu.edu.sa, srafatullah@yahoo.com
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Abstract:

Antinociceptive, anti-inflammatory and antipyretic effects of a flavonoidal mixture collected from the leaf surface of Rhus retinorrhaea Steud. ex. A. Rich. (FMRR) (Family: Anacardiaceae) was studied on mice and rats. Antinociceptive activity was determined using both chemical and thermal methods of nociception in mice. In chemical method acetic acid writhing test and in thermal methods hot plate and tail flick tests were performed. Anti-inflammatory tests were conducted on rats using carrageenan-induced hind paw edema and cotton pellet granuloma. A dose-dependent algesia and hyperpyrexia was recorded in mice by flavonoid mixture. The flavonoid mixture suspension at doses of 100 and 200 mg/kg body weight produced a significant inhibition of carrageenan-induced paw edema and cotton pellet granuloma in rats. The acute toxicity tests showed no mortality or morbidity in mice up to a 3 g/kg bwdose

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