NEW THIOUREIDES OF 2-THIOPHENEACETIC
ACID WITH POTENTIAL PHARMACOLOGICAL
ACTIVITY. NOTE 1.
CARMELLINA DANIELA BĂDICEANU, ALEXANDRU MISSIR
Pharmaceutical Chemistry Department, Faculty of Farmacy, „Carol
Davila” University of Medicine and Pharmacy , Traian Vuia 6, sect. 2,
020956, Bucharest, Romania
*corresponding author: bcarmellina@yahoo.com
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Abstract:

It is well known that many compounds bearing thioureide structure have been reported to have antimicrobial activity. Some compounds with thioureide structure, are found to be associated with different therapeutical activities such as antifungal, antiviral, antitumoral, anthelmintic, diuretic, anticonvulsant, antidiabetic, insecticidal or pesticidal. [1].
Our experience [2-6] in synthesis and characterization of new thioureides with potential pharmacological activity lead us to expand these studies and to obtain new thioureides of 2-thiopheneacetic acid.
The new compounds are prepared in two stages by addition of some primary aromatic amines at 2-thienyl isothiocyanate. Chemical structure of the synthesized compounds has been elucidated by their ¹H-NMR and ¹³C-NMR spectra.

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