ASSAY OF NIMESULIDE BY
ION ASSOCIATION TITRATION.
IOANA CLEMENTINA CONSTANTINESCU, MARINELA
FLOREA*, CORINA-CRISTINA ARAMĂ, ANGELA NEDELCU,
CRINA-MARIA MONCIU
University of Medicine and Pharmacy “Carol Davila” Bucharest,
Faculty of Pharmacy, Department of Analytical Chemistry,
6th Traian Vuia str, Bucharest 2, 020956
*corresponding author: florea.marinela@gmail.com
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Abstract:

The present paper presents a new two-phase titrimetric method for the assay of nimesulide. The method is based on the solvent extraction of nimesulide using tetradecyltrimethylammonium bromide (cetrimide) as ion association reagent. Thymol blue was used as indicator. The proposed method was successfully applied to the nimesulide assay in bulk and pharmaceutical dosage forms.

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