SCANNING ELECTRONIC MICROSCOPY STUDY
OF NEW PYRAZINAMIDE COMPOUNDS WITH
METALLIC IONS.
TÜNDE JURCA*, ELEONORA MARIAN
Oradea University, Faculty of Medicine and Pharmacy, Speciality of
Pharmacy, Department of Inorganic Chemistry, 29 Nicolae Jiga Street,
410028, Oradea, România
*corresponding author: tjurca@uoradea.ro
Download Full Article
Abstract:
In this study it is presented the preparation method of two pyrazinamide
compounds with transitional metal ions, their physico-chemical properties, the results of the
elementary analysis, as well as the examination by scanning electronic microscopy of these
compounds’ particles form. The FT-IR (4000-400 cm-1) spectra of pyrazinamide (PZA),
[Cu(PZA)2]Cl2 and [Cu(PZA)2(C6H5COO)2 were recorded. The observed wavenumbers were
analyzed and assigned to different normal modes of vibration of the molecule.
Pyrazinamide (PZA) is among the first-line drugs for the treatment of
tuberculosis, which seems to reappear as a frequent disease.
With the assistance of the scanning electronic microscopy, the granules’ surface
aspect may be observed, the X-ray spectra that show the presence of the elements on the
analyzed micro area and the chemical composition diagram per granule for each newly
synthesized compound.
The examinations were performed using the scanning electronic microscope
SEM type Jeol 5600 LV, equipped with an X-ray spectrometer type Oxford Instrument.
Details concerning the spatial architecture and the crystalline structure will be
obtained by vibration spectroscopy of magnetic resonance and X-ray diffraction..
Top