PHARMACO-TOXICOLOGICAL RESEARCHES UPON SOME NEW COMPOUNDS FROM BISACETANILIDES CLASS.
TEODOR OCTAVIAN NICOLESCU^1*, CORINA ANA IONIŢĂ²
University of Medicine and Pharmacy “Carol Davila”, Faculty of
Pharmacy, 6 Traian Vuia Street, Bucharest, Romania
1Organic Chemistry Department
2Clinical Laboratory Department
*corresponding author nicolescu.teodor@gmail.com
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Abstract:

The purpose of the study was to determine the acute toxicity (LD₅₀) on mice as well as to distinguish the main pharmacological actions (analgesic action and local anaesthetic conducting action) of some new compounds from bis-acetanilides class. Pharmaco-toxicological tests were performed on white mice series. The acute toxicity expressed by LD₅₀ ranged between 802 and 964.5 mg/Kg body weight orally administered. The algogenic effect compared to noraminophenazone varied between 72.44% and 78.65%. The local anaesthetic conducting action was moderated for the majority of studied compounds, compared to lidocaine – a structure related compound. One of the compounds presented 82.24% from its action.

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