EXPERIMENTAL RESEARCH ON MICE REGARDING THE IMPLICATION OF MELATONIN IN PAIN MANAGEMENT.
ANDREEA LETIŢIA NIŢULESCU-ARSENE¹, NICULINA MITREA¹,
AURELIA CRISTEA², CRISTINA MANUELA DRĂGOI¹
University of Medicine and Pharmacy „Carol Davila”, Bucharest,
Faculty of Pharmacy, Traian Vuia no. 6
1Department of Biochemistry
2Department of Pharmacology and Clinical Pharmacy
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Abstract:

Melatonin (N-acetyl-5-methoxytryptamine) is the main hormone biosynthesized by the pineal gland. This biomolecule coordinates and synchronizes the expression of the most important physiologic sleep-awake effects and biological rhythms. Numerous studies in the scientific literature also describe its multi-regulatory roles in endocrine, immune and
nervous systems. Recently, melatonin has been suggested to play a regulatory role in organisms’ pain sensitivity. Our previous studies investigated the antinociceptive activity of melatonin when we performed an evaluation regarding the dose-dependent dinamics of the analgesic effect of melatonin. We found that the biomolecule exerts an important analgesic effect for the dose of 50mg melatonin/kgbw.
The present study investigated the antinociceptive pharmacologic effects of
melatonin (50mg/kgbw, i.p.) in co-administration with ondansetron (4mg/kgbw, i.p.), petidine (4mg/kgbw, i.p.) and tramadol (3.5mg/kgbw, i.p.).
Experiments were performed in vivo, using Albino Swiss male mice. Pain sensitivity was assessed using the hot-plate test (60°C).
The present study also outlines an amplification of the analgesic effect when petidine is co-administered with melatonin and an antagonism between ondansetron and the pineal biomolecule..

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