FORMULATION AND PHARMACEUTICAL
EVALUATION OF THREE W/O EMULSIONS
WITH MYTILUS GALLOPROVINCIALIS LMK.
AND RAPANA VENOSA LIPID EXTRACTS.
DIANA BADIU1*, FLORENTINA RONCEA2, NATALIA ROŞOIU3
1”Ovidius” University, Faculty of Biology, Department of Biochemistry,
Constanta, dianabadiu@yahoo.com
2”Ovidius” University, Faculty of Pharmacy, Department of
Pharmaceutical Techniques, Constanta
3”Ovidius” University, Faculty of Medicine, Department of Biochemistry,
Constanta
*corresponding author: dianabadiu@yahoo.com
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Abstract:
The present paper presents new formulations of three lipid extracts of Mytilus
galloprovincialis Lmk., Rapana venosa molluscs and those mixed (1:1, v/v) through their
incorporation in W/O emulsions. These consisted of 4% lipid extracts (active ingredients),
60% liquid paraffin as the oil phase, 3% glycerin, 25.96% water as the water phase, 6%
Span 60 as the surfactant and 0.04% nypagin as preservative. The smell was adjusted with
1% Oleum lavandulae.
The scope of this study regards the formulation and pharmaceutical evaluation of
the three W/O emulsions. Their evaluation consisted of: aspect, colour, smell, type of
emulsion by dilution, electric conductibility and total dissolved salts (TDS) methods,
dynamic viscosity, stability by heating at 700C and centrifugation at 3000 rpm, pH and
tension determinations.
The results showed a good stability over 90 days of observation period of the
three emulsions evaluated through the pharmaceutical parameters.
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