STUDY ON THE INFLUENCE OF SOME FORMULATION VARIABLES AND AGEING ON W₁/O/W₂ DOUBLE EMULSIONS STABILITY BY RHEOLOGICAL MEASUREMENTS.
LAVINIA URŞICA*, VICENŢIU VLAIA, GEORGETA CONEAC, LENUŢA-MARIA MICLEA, ALINA HEGHEŞ, IOANA OLARIU
University of Medicine and Pharmacy „Victor Babes”, Faculty of Pharmacy, Department of Pharmaceutical Technology, P-ta Eftimie Murgu, No. 2, 300041, Timişoara, Romania
*corresponding author: laviniaursica@yahoo.com
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Abstract:

The aim of this work was to study the influence of some formulation variables and ageing on the stability of some water-in-oil-in-water (W1/O/W2) double emulsions by rheological measurements. W₁/O/W₂ double emulsions were prepared using the two-step procedure. The varied parameters of formulations were the hydrophilic macromolecule compound dispersed in the internal aqueous phase (gelatine and hydroxyethylcellulose) and its pH. Rheological behavior and viscosity of the obtained W₁/O/W₂ double emulsions were measured immediately, 1 month and 3 months respectively, after preparation.
The obtained results demonstrated that the studied W₁/O/W₂ double emulsions remained stable during the observation period, although they exhibited some differences regarding their rheological properties caused by formulation variables and ageing.

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