CORRELATIONS BETWEEN SOME PLASMATIC REDOX PARAMETERS IN DIABETIC PACIENTS.
VLAD GRUIA, ANDREEA ARSENE-NIŢULESCU, MOHORA MARIA, NICULINA MITREA, DANIELA GRADINARU, BEGONA Y. MANUEL
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Abstract:

The purpose of the study was to assess the correlations existing between the length of time from diabetes onset and some redox parameters expressed at plasmatic level.
In order to assess the damaging evolution of oxidative stress for the complications of diabetes mellitus, we designed a clinical study in which we tried to establish possible correlations between the length of time from diabetes onset and some redox parameters expressed at plasmatic level.
We included 70 pacients, 40 of them living in Romania while the rest of the subjects (30) were from Belgium. The following data was recorded: age, year of diabetes diagnosis (the onset of diabetes), fasting plasma glucose, total cholesterol and serum lipoproteins (high density lipoproteins - HDL, low density lipoproteins - LDL, triglycerides – TG).
The pacients were divided into three groups, according to the length of time from diabetes onset: group 1 – no more than 10 years, group 2 - between 11-20 years and group 3 – more than 20 years.
The parameters indicating the blood redox status were: the erythrocyte superoxiddismutase (SOD), the plasmatic malondialdehyde (MDA), total antioxidant plasmatic capacity (TEAC), plasmatic vitamin C and E, using spectrophotometric and HPLC methods [4].
Our results outlined interesting corelations between pacients diabetes onset and the redox status. The activity of SOD and the level of MDA were increased for the group 1 compared with both group 2 and 3. The same pattern was noticed in respect to the plasmatic level of MDA, vitamin C and vitamin E. However the values of TEAC did not show any important modifications between the three studied groups.

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