MODULATION OF TRAMADOL ANTINOCICEPTION BY KETAMINE AND BACLOFEN IN MICE.
SORINA CUCUIET, G. DOGARU, VERONICA NASTASA BILD, MARIA T. DOGARU
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Abstract:

The paper presents the influence of two coanalgesics (ketamine and baclofen) on the antinociceptive effect of tramadol, a synthetic opioid with monoaminergic activity, mild efficacy, but low respiratory depression and reduced abuse potential in order to increase its efficacy. The study was performed on Albino mice using the hot plate test (the classical method) and also by a modern method of analyzing interactions - the method of fixed-ratio combination (composite additive line). The results showed that ketamine and baclofen exerted their own antinociceptive effect using the hot plate test. Ketamine (0.25 and 0.5 mg/kgbw) intensified significantly the analgesic effect of small doses of tramadol in simultaneous administration, and baclofen (1.25; 2.5 and 5 mg/kgbw) increased statistically significant the antinociceptive effect of tramadol.Using the method of fixed-ratio combination, there was determined the effective dose for each substance, respectively the interaction index. In conclusion, this study showed an aditive synergistic interaction between tramadol and these two coanalgesics. The authors suggest that such combinations could have therapeutical applications, but only after being tested in clinical studies.

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