STUDY ON THE INFLUENCE OF THE TREATMENT WITH SOME NEWLY SYNTHESIZED ANTIGLAUCOMA PROSTAMIDES ON THE HEMATOLOGICAL PARAMETERS ON RATS.
DENISA IOANA UDEANU, DENISA MIHELE, FLOREA COCU, GEORGETA CARAENE, VIRGINIA VULTURESCU, DANIELA IOVA
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Abstract:

Prostamides (prostaglandin-ethanolamides) are a new class of fatty acid amide compounds. They are cyclo-oxigenase-2 (COX-2) derived oxidation products of endocannabinoid/ endovaniloid anandamide. Prostamides are nowadays considered the most effective drugs used for the long term treatment of primary open angle glaucoma. Some new prostamides with potential antiglaucoma action were synthesized within the Department of Biosynthesis of Natural Products from the National Institute for Chemical and Pharmaceutical Research and Development, Bucharest. The present paper aims to determine the acute toxicity of newly synthesized prostamides with ocular antihypertensive action and also their treatment influence on some hematological parameters within the preliminary studies.

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