SCREENING FORMULATION AND TEHNOLOGICAL VARIABLES OF A FLUIDIZED BED GRANULATION ON THE CHARACTERISTICS OF GRANULES AND TABLETS CONTAININING METOPROLOL.
C. ALECU, I. TOMUŢĂ, L.L. RUS, S.E. LEUCUŢA
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Abstract:

The aim of this experimental work was to perform a screening of some formulation and technological factors on a laboratory scale fluid bed granulation process on the characteristics of granules and tablets with metoprolol. In order to perform the study, a fractioned factorial experimental design (5 factors, 2 levels) was used. The following factors were studied: the atomization pressure, the spraying rate, the amount of intra- and extra-granular disintegrant used, the amount of intra-granular lactose used.
We found that the most significant influences of the studied factors on the properties of the granules and the tablets were: increase of atomization pressure causes the decrease of mean diameter of granules and decrease in granules density (both untapped and tapped); increase of the spray rate leads to the increase of the mean diameter, to an increase of granule density and to a better flowability and compressibility properties of the granules; increase of the ratio of extra-granular disintegrant and the ratio of intra-granular lactose leads to a shorter disintegration time.

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