SPECTROPHOTOMETRIC DETERMINATION OF NIMESULIDE THROUGH ION-PAIR COMPLEX FORMATION WITH HEXADECYLTRIMETHYLAMMONIUM BROMIDE.
MARINELA FLOREA, CRINA-MARIA MONCIU, ANDRIŢOIU MAGDA LAURA, BĂCANU LAVINIA GABRIELA
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Abstract:

The present work reports a new spectrophotometric method for nimesulide assay. This is based on nimesulide ability to form with hexadecyltrimethylammonium bromide (cetrimide), in basic media, an ionic association extractible in chloroform, with a maximum at 404 nm. The method was validated and applied with good results on nimesulide assay in pharmaceutical dosage forms.




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