DEVELOPMENT OF HYDROPHILIC SWELLABLE CARBOPOL MATRIXES FOR EXTENDED RELEASE OF ALENDRONATE TABLETS.
LACRAMIOARA OCHIUZ, GRATIELA POPA, ELIZA GAFITANU
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Abstract:

Alendronate (AL), is an antiresorptive agent used in both prophilaxy and treatment of all types of osteoporosis. Oral administration of AL induces a very low bioavailability (less than 1%), which can be increased by various technological methods. For this purpose we formulated extendend release oral delivery system as hydrophilic matrix tablets based on Carbopols. The main objective of the study was to compare the hydratation and swelling characteristics of matrix tablets formulated using three sorts of Carbopol with different levels of crosslinker: Carbopol 974 P NF, Carbopol 971 P NF, Carbopol 71 G NF. The matrix tablets were prepared by direct compression, being formulated in four different concentrations for each type of Carbopol that has been studied, using the same excipients (Ludipress-diluent, Magnesium stearate-lubricant).
The tablets were evaluated in regard to: weight uniformity, thickness, diameter, hardness, friability, dynamic hydratation and swelling behavior.
According to our results the formulations containing 15% carbopol generate tablets that exhibit the best swelling and erosion characteristics, being recommended for the preparation of the extended release alendronate tablets.

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