SKIN TOXICITY EVALUATION FOR SOME SODIUM LAURYL SULPHATE CREAMS.
A DOSE-DEPENDENT RELATIONSHIP FOR ANIONIC SURFACTANT.
SIMONA ARDELEAN, CRISTINA A. DEHELEAN, CODRUŢA ŞOICA, BRÂNDUŞA DUMITRIU, LAVINIA URŞICA, VICTOR NĂSTASE
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Abstract:

Surfactants represent an auxiliary substance category, as they are used in both pharmaceutical and cosmetic products; there are demands to analyse the surfactants for quality and safety.
In the category of tensioactive compounds, the role of anionactive group was re-evaluated and the possibilities that confer the safety of the products containing these ingredients after a long-term utilization were outlined. It is proven that the semisolid forms containing these emulsifying compounds are of high quality. The frequent use of tensioactive products leads to the noxiousness study of these compounds and the establishing of a very exact dose-effect relationship. The study tries to analyse these aspects of the noxious reactions of surfactants by modern tests: transepidermal water loss (TEWL), moistening degree, etc. The main conclusion is that tensioactives like sodium lauryl sulphate can determine important skin toxicity on concentrations higher than 10%.

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