THE IDENTIFICATION AND ASSAY OF KETOPROFEN FROM SOLID PHARMACEUTICAL FORMS. VALIDATION OF HPLC METHOD.
MARIANA GANEA, SANDA BOTA, FELICIA GLIGOR, CORINA MOISA, LAURA VICAŞ, MARIUS BOJIŢĂ
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Abstract:

Ketoprofen belongs to the nonsteroidal anti-inflammatory group of drugs (NSAID), and plays an important role in today’s therapy due to its anti-inflammatory, analgesic and antipyretic action.
The study presents a HPLC method for the quantification of ketoprofen in solid pharmaceutical dosage forms. In the same time, we have made a study in order to validate the proposed method. For this purpose, the assay has been performed following the validation parameters: linearity, repetability, detection limit and quantification limit. The proposed method for assaying of ketoprofen from solid pharmaceutical dosage forms is a precise method, in accordance to all the validation parameters.




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