KINETIC MODELING OF HYDRATION HYDROPHILIC MATRICES WITH DICLOFENAC SODIUM ON BASIS OF HYDROXYPROPYL METHYLCELLULOSE AND XANTHAN GUM.
I. KUSAI, L.VLASE, I. TOMUŢĂ, S.E. LEUCUŢA
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Abstract:

The use of natural matrices containing either Xanthan gum or Hydroxypropyl methylcellulose, as release-controlling-release agents, was studied. These polymers hydrate and swell in contact with water and they are used for the preparation of single unit matrix dosage forms.
The aim of this study was the analysis of hydration kinetics of several formulations of hydrophilic matrices containing hydroxypropyl methylcellulose and Xanthan gum, diclofenac sodium loaded. A number of 21 formulations were prepared and analyzed, which differ by polymer type, the polymers’ moisture effect, the polymers’ratio (between Hydroxypropyl methylcellulose / Xanthan gum) and also the proportion between polymers and active drug substance. The degree of hydration was evaluated by a gravimetric method [1, 2].
By application of various mathematical models, it was possible to quantify and to describe the mechanism of hydration of different kinds of hydrophilic matrices. The representative model describing the kinetics of hydration for these matrices was Peppas model and its characteristic parameters were calculated and analyzed.

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