UV-VIS SPECTROPHOTOMETRIC ASSAY OF METOPROLOL.
NOTE 2. METHOD VALIDATION.
MAGDALENA BĂDULESCU, DAN BĂLĂLĂU,
IOANA CACOVEAN, MIHAELA ILIE, DANIELA LUIZA BACONI
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Abstract:

Metoprolol is a widely used beta-blocker mostly administrated in cardiovascular diseases. Due to the highly probable overdosage, a rapid and easy to perform method for the quantitative determination of metoprolol tartrate in biologic matrices would be useful in its therapeutic monitoring as well as in intoxication cases.
The paper presents two validated methods for the UV-VIS quantitative assay of metoprolol tartrate in tablets: the UV direct method and the oxidative method with potassium permanganate. The parameters targeted for the validation were: specificity, range, detection and quantification limits, accuracy, and precision.




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