SERUM OXIDATIVE STRESS PARAMETERS AND HOMOCYSTEINE LEVELS IN PATIENTS WITH RENAL TRANSPLANT.
ANGELA ANTONESCU, MARIANA MUREŞAN, OTILIA MICLE, LIANA MICLE, LUCIANA DOBJANSCHI, LAURA VICAŞ, M. DOROFTEIU
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Abstract:

The aim of our study was to determine the level of homocysteine, oxidativ stress markers and the lipidic profile in pacients with renal transplant.
The researches included 25 patients with renal transplant followed up four months (from March until June 2007). It was evaluated the levels of lipid peroxides (a colorimetric method with thiobarbituric acid) and ceruloplasmin (Ravin method). The concentration of homocysteine was assessed using an enzymatic method.
We also measured the concentration of cholesterol and tryglicerides. All the results were compared with a control group.
The patients presented an oxidative stress reflected by a high level of malondialdehide (MDA) compared to the control group. The concentration of ceruloplasmin was reduced. They also showed a hiperhomocysteinemia. Cholesterol level was in a normal range, and the triglycerides increased.

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