THE LANTHANIDES: PHYSICO–CHEMICAL PROPERTIES RELEVANT FOR THEIR BIOMEDICAL APPLICATIONS.
CARMEN MARIA STURZA, RICA BOSCENCU, VERONICA NACEA
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Abstract:
Over the past ten years a resurgence of interest in the lanthanides chemistry has been noticed, especially in the biomedical applications of these elements. In this review we try to demonstrate that for the biomedical applications of lanthanides their spectral, magnetic and coordinative properties are essential.
The lanthanides represent the largest naturally occurring group of elements in the periodic table. They are highly electropositive and reactive metals. Spectral and magnetic properties of lanthanide ions are remarkable. Their coordination chemistry is complicated, especially in solutions having not well defined stereochemistry and uncertain coordination numbers. However, the complexes of lanthanides and even the lanthanide salts are getting more and more applications in biology, biochemistry and medicine.
The chelates of lanthanide ions are used as labels in fluorescent immunoassays. The paramagnetic and luminescent Tb+3- phosphatidylcholine-complexes are unique evidence for the cation phospholipid interaction. Water-soluble La+3 and Eu+3 complexes are effective in detecting sugars neutral environment and glycolipids and phospholipids as well. Furthermore, literature data show that some simple lanthanide salts and complexes exhibit an antitumoral activity.
All above reveal the actuality of the subject.
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