MANUFACTURING PROCESS AND CHARACTERIZATION OF SOME BETA-CAROTENE TABLETS.
EMMA CREŢU, VICTORIA HÎRJĂU, MIRCEA HÎRJĂU, TEODORA BALACI, ANDREEA STĂNESCU, MIRELA MITU
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Abstract:

The aim of this study was to attempt to improve the production technology of beta-carotene tablets. It is a well known fact that beta-caroten is described as red-brown to dark-purple crystals, highly sensitive to high temperatures and oxidizing agents. Thus, its formulation as tablets by conventional methods with optimum stability is difficult to achieve, the pharmaceutical industry prefers to manufacture soft gellatin capsules with beta-carotene.
Using a direct compressible (DC) powder with a 10 % content in beta-carotene, containing the drug incorporated in a starch-coated gelatin and sucrose matix, we have obtained tablets with various concentrations in active substance (6, 7 and 12 mg). The coprocessed blend contained some antioxidant agents (tocopherole, sodium ascorbate and ascorbyl palmitate) and an anti-caking agent (tricalcium phosphate). Beta-carotene was associated with vitamins C and E in direct compressible forms, thus accentuating its effect and protecting it from oxidation [1].
The tablets were then subjected to quality control, with optimal results, showing that suitable tablets can be obtained using the proposed materials.

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