THE OPTIMIZATION OF PROLONGED RELEASE OF MATRIX TABLETS WITH FELODIPINE.
R.I. IOVANOV, I. TOMUTA, S.E. LEUCUTA
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Abstract:

The objective of this work was to prepare and optimize some prolonged release matrix type tablets with felodipine based on Kollidon SR, in order to obtain similar release profiles with the original product. In this regard a full experimental design with 2 factors and 3 variables was used in order to observe the influence of the formulation variables on the characteristics of the tablets. The studied variables where: percent of Kollidon SR in the tablet and diferent fillers. The tablets where characterized from the point of view of the pharmaceutical properties (mechanical strength, friability and in vitro dissolution behavior). The results showed that the percent of Kollidon SR in the tablets has the biggest effect on the release of felodipine. The optimum formula generated from the experimental data was similar with the original product.

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