THE INFLUENCE OF SOME HYDROPHILLIC POLYMERS UPON DILTIAZEM HYDROCHLORIDE DISSOLUTION FROM MATRIX DOSAGE FORMS FORMULATION.
CAMELIA BALAZS, SORIN E. LEUCUTA
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Abstract:

Matrix tablets containing diltiazem hydrochloride were prepared by the direct compression method, using hydrophilic polymers, hydroxypropyl methylcellulose (HPMC, type Methocel K15M), hydroxypropyl cellulose (HPC, type Klucel HXF) and polyethylene oxide (PEO, type Polyox 1105). Diltiazem hydrochloride dissolution from matrix tablets was in accordance with the hydrophilic polymer type and level. Hence, it was obtained a slow release for diltiazem. The in vitro release of diltiazem was determined using UV spectrophotometry at 237 nm. Results, in conformity with the requirements of one dissolution test for diltiazem, from U.S.P., can be obtained with formulations based on PEO. The diltiazem release mechanism from hydrophilic matrices was observed by correlation with kinetic models.

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