COMPLEXATION WITH HYDROXYPROPYL-γ-CYCLODEXTRIN OF SOME PENTACYCLIC TRITERPENES. CHARACTERISATION OF THEIR BINARY PRODUCTS.
CODRUŢA M. ŞOICA, CRISTINA A. DEHELEAN, CAMELIA I. PEEV, GEORGETA CONEAC, ALEXANDRA T. GRUIA
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Abstract:

Pentacyclic triterpenes possess anticancer, anti-inflammatory and antiviral activity. The compounds can be obtained by simple extraction with organic solvents. The major problem of this type of triterpenes is their low water solubility which can be increased by physical procedures like cyclodextrin complexation. The aim of present study was to analyse the products obtained between pentacyclic triterpenes (betulinic acid, betulin) and hydroxipropil-γ-cyclodextrin (HPGCD). HPGCD is a hydrophilic semi synthetic cyclodextrin cited in literature as a complexation agent for compounds like betulinic acid, so it was used as a host-molecule to improve its solubility in water. In order to obtain the inclusion complexes, 1:2 molar ratio and two preparation methods (physical mixing, kneading) were used. The inclusion complexes were analysed by in vitro dissolution tests and X-ray diffraction and then submitted to MTT test on mesenchimal stem cells.

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