CONSTRUCTION AND CHARACTERISATION OF A MEMBRANE SELECTIVE ELECTRODE FOR RANITIDINE HYDROCHLORIDE.
MIHAI APOSTU, NELA BIBIRE, GLADIOLA ŢÂNTARU
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Abstract:

A membrane selective electrode for the determination of ranitidine hydrochloride was developed, based on ranitidine - picrate as electroactive substance. For pH 4.0, the linear response range, slope (25ºC) and quantification limit of the electrode were 1.0×10-5 - 1.0×10-1 M, 29.98 mv per decade and 3.98×10-6 M, respectively. The electrode was successfully applied for the determination of ranitidine hydrochloride in tablets and injectable solutions by direct potentiometric method.




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